Basal cell carcinoma - Karsinoma Sel Basal
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Lesi ulcer sing mengaruhi kulit irung ing wong tuwa asring didiagnosis minangka Karsinoma Sel Basal (Basal cell carcinoma). Irung minangka situs umum kanggo kanker kulit jinis iki.
Karsinoma Sel Basal (Basal cell carcinoma) bisa uga ana wates lan borok sing ora teratur.
Karsinoma Sel Basal (Basal cell carcinoma) bisa disalahake minangka kutil.
References
Basal cell carcinoma (BCC) minangka jinis kanker kulit sing paling umum. Cahya srengenge minangka panyebab utama. Meh kabeh kasus BCC nuduhake sinyal Hedgehog sing aktif banget ing analisis molekuler. Pangobatan sing beda kasedhiya lan dipilih adhedhasar risiko kambuh, pentinge pengawetan jaringan, preferensi pasien, lan tingkat penyakit.
Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease.
Basal cell carcinoma (BCC) is the most common malignancy. Exposure to sunlight is the most important risk factor. Most, if not all, cases of BCC demonstrate overactive Hedgehog signaling. A variety of treatment modalities exist and are selected based on recurrence risk, importance of tissue preservation, patient preference, and extent of disease.
Basal cell carcinomas minangka jinis kanker kulit sing paling umum ing wong diwasa kanthi kulit putih umur 50 lan luwih. Jumlahe saya mundhak ing saindenging jagad, utamane amarga sinar srengenge. Kahanan genetis tartamtu bisa nggawe wong cenderung ngalami kanker kasebut nalika umure luwih enom. Basal cell carcinomas beda-beda ing tingkat keruwetan, wiwit saka lesi entheng utawa nodular sing gampang diobati nganti luwih akeh sing mbutuhake diskusi ing tim medis khusus. Prognosis gumantung saka kemungkinan kanker bali utawa kemampuan kanggo ngrusak jaringan sing cedhak. Surgery minangka perawatan standar kanggo umume kasus, njamin mbusak sing tepat lan kemungkinan kambuh. Cara sing kurang invasif bisa kanthi efektif ngobati lesi sing entheng.
Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. The prognosis is linked to the risk of recurrence of basal cell carcinoma or its local destructive capacity. The standard treatment for most basal cell carcinomas is surgery, as it allows excision margin control and shows a low risk of recurrence. Superficial lesions can be treated by non-surgical methods with significant efficacy.
Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. The prognosis is linked to the risk of recurrence of basal cell carcinoma or its local destructive capacity. The standard treatment for most basal cell carcinomas is surgery, as it allows excision margin control and shows a low risk of recurrence. Superficial lesions can be treated by non-surgical methods with significant efficacy.
Perawatan utama kanggo BCC yaiku operasi. Kanggo BCC sing beresiko dhuwur utawa berulang, utamane ing wilayah kritis, operasi sing dikontrol mikrografi dianjurake. Pasien karo BCC superficial beresiko rendah bisa uga nimbang perawatan topikal utawa cara sing ngrusak. Terapi fotodinamik bisa digunakake kanggo BCC nodular sing entheng lan beresiko rendah. Kanggo BCC maju utawa metastatik lokal, inhibitor Hedgehog (vismodegib, sonidegib) dianjurake. Yen ana perkembangan penyakit utawa intoleransi marang inhibitor Hedgehog, imunoterapi kanthi anti-PD1 antibody (cemiplimab) bisa dianggep. Radioterapi minangka pilihan sing apik kanggo pasien sing ora bisa operasi, utamane pasien tuwa. Electrochemotherapy bisa dianggep yen operasi utawa radioterapi ora dadi pilihan.
The primary treatment for BCC is surgery. For high-risk or recurring BCC, especially in critical areas, micrographically controlled surgery is recommended. Patients with low-risk superficial BCC might consider topical treatments or destructive methods. Photodynamic therapy works well for superficial and low-risk nodular BCCs. For locally advanced or metastatic BCC, Hedgehog inhibitors (vismodegib, sonidegib) are recommended. If there's disease progression or intolerance to Hedgehog inhibitors, immunotherapy with anti-PD1 antibody (cemiplimab) can be considered. Radiotherapy is a good option for patients who can't have surgery, especially older patients. Electrochemotherapy could be considered if surgery or radiotherapy isn't an option.
The primary treatment for BCC is surgery. For high-risk or recurring BCC, especially in critical areas, micrographically controlled surgery is recommended. Patients with low-risk superficial BCC might consider topical treatments or destructive methods. Photodynamic therapy works well for superficial and low-risk nodular BCCs. For locally advanced or metastatic BCC, Hedgehog inhibitors (vismodegib, sonidegib) are recommended. If there's disease progression or intolerance to Hedgehog inhibitors, immunotherapy with anti-PD1 antibody (cemiplimab) can be considered. Radiotherapy is a good option for patients who can't have surgery, especially older patients. Electrochemotherapy could be considered if surgery or radiotherapy isn't an option.
Faktor risiko kalebu paparan sinar ultraviolet, terapi radiasi, paparan arsenik jangka panjang lan fungsi sistem kekebalan sing kurang (contone, transplantasi organ). Paparan sinar UV nalika isih cilik mbebayani banget.
Sawise diagnosa kanthi biopsi, perawatan biasane ditindakake kanthi bedah. Iki bisa kanthi eksisi prasaja yen kanker cilik; Yen kanker ora cilik, operasi Mohs umume dianjurake.
Karsinoma sel basal nyebabake paling ora 32% kabeh kanker ing saindenging jagad. Saka kanker kulit saliyane melanoma, udakara 80% minangka kanker sel basal. Ing Amerika Serikat, kira-kira 35% lanang putih lan 25% wanita putih kena pengaruh karsinoma sel basal ing sawetara titik ing urip.
○ Diagnosis lan Perawatan
#Dermoscopy
#Skin biopsy
#Mohs surgery